Monoclonal Antibody–Mediated Toxicity inCryptococcus neoformansInfection: Mechanism and Relationship to Antibody Isotype
نویسندگان
چکیده
منابع مشابه
Mechanism for the isotype dependence of antibody-mediated toxicity in Cryptococcus neoformans-infected mice.
Ab-based therapies have undergone a renaissance in recent years, but infusion-related reactions are a significant clinical problem. Administration of certain mAbs to Swiss Webster mice infected with Cryptococcus neoformans can result in acute lethal toxicity (ALT) characterized by cardiovascular collapse. The ability of a mAb to produce ALT is isotype dependent and occurs with IgG1 but not IgG3...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 1999
ISSN: 0022-1899,1537-6613
DOI: 10.1086/314946